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Jan 21-23 2019

Training school

Training School: Risk modeling in colorectal cancer

21st January 2019-23rd January 2019

Hospitalet de LLobregat, Barcelona, Spain

Identifying Biomarkers Through Translational Research for Prevention and Stratification of Colorectal Cancer (TRANSCOLONCAN)

Monday 21st

14:00-16:00 Basics of predictive modeling (Victor Moreno)

  • Study design
  • Analysis strategy
  • Data preprocessing
  • Over-fitting. Internal and external validation.
  • Statistics for predictive modeling
  • Assessment of accuracy
  • Model calibration

16:30-18:30 Computer exercises (M.Henar Alonso & Victor Moreno)

  • Simple model building (logistic regression)
  • Assessment of predictive accuracy
  • Bootstrap and cross validation with R

Tuesday 22nd

09:00-11:00 Predictive modeling tools and strategies (Victor Moreno)

  • Logistic regression
  • Elastic nets
  • Support vector machines
  • Trees and Random forests
  • Boosting
  • Neural networks
  • Feature selection and predictor importance

11:30-13:00 Computer Exercises of analysis with R (M.Henar Alonso & Victor Moreno)

  • Model building
  • Model assessment
  • Feature selection

13:00-14:00 Lunch

14:00-16:00 Genetic risk models (Victor Moreno & Robert Carreras)

  • Overview of genome-wide association studies (GWAS) data and analysis
  • Genetic risk scores
    • Building genetic scores
    • Models with genetic scores
  • Mendelian randomization
  • GWAS correlations

16:30-18:30 Computer exercises (Robert Carreras & Anna Diez)

  • Capitalizing GWAS data to identify risk factors
    • Mendelian randomization (hands-on training; MR-base)
    • GWAS correlations (hands-on training; LD-Hub)

Wednesday 23rd

09:00-11:00 Integrating GWAS and gene-expression data (Robert Carreras)

  • Transcriptome-wide association studies (TWAS) overview
  • TWAS correlations
  • Overview of mutational signatures on somatic tumor tissue

11:30-13:00 Examples of genetic risk models (Sergi Castellvi)

  • Paper review of paradigmatic examples
  • Reporting guidelines STARD, REMARK
  • Public health interpretation of risk models

13:00 Lunch

COST is supported by the EU Framework Programme Horizon 2020